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Download ebook Muerte Neuronal En La Enfermedad de Huntington
Download ebook Muerte Neuronal En La Enfermedad de Huntington
---------------------------------------------------------------
Author: Massieu Trigo Lourdes
Number of Pages: 104 pages
Published Date: 07 May 2014
Publisher: Publicia
Publication Country: United States
Language: Spanish
Format: Pdf
ISBN: 9783639551952
File Name: Muerte.Neuronal.En.La.Enfermedad.de.Huntington.pdf
Download Link: Muerte Neuronal En La Enfermedad de Huntington
---------------------------------------------------------------
La enfermedad de Huntington (EH) es un padecimiento hereditario, neurodegenerativo que se caracteriza por la presencia de movimientos involuntarios, demencia y alteraciones psiquiatricas. La mutacion de la proteina conocida como "huntingtina" lleva al desarrollo de la EH, afectando principalmente la funcion de las neuronas espinosas medianas (NEM) en el caudado-putamen (estriado). Desafortunadamente, las NEM no pueden compensar los cambios originados por la huntingtina y eventualmente mueren. Se ha sugerido que a traves de un mecanismo excitotoxico (toxicidad mediada por el glutamato), ya que alteraciones en los componentes de la transmision glutamatergica ocurren tempranamente en pacientes y modelos transgenicos de la EH. En este trabajo evaluamos la toxicidad del glutamato en el estriado de un modelo transgenico de la EH. Tambien estudiamos la relacion entre la excitotoxicidad y los niveles de los transportadores de glutamato en la EH. Nuestros resultados indican que las NEM son mas vulnerables a la toxicidad mediada por glutamato; el desarrollo de un evento excitotoxico en la EH esta estrechamente relacionado con los cambios funcionales de los transportadores glutamato."
Read online Muerte Neuronal En La Enfermedad de Huntington Buy and read online Muerte Neuronal En La Enfermedad de Huntington Download and read Muerte Neuronal En La Enfermedad de Huntington ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent Download to iPad/iPhone/iOS, B&N nook Muerte Neuronal En La Enfermedad de Huntington
Muerte Neuronal En La Enfermedad de Huntington. Massieu Trigo Lourdes
Author: Massieu Trigo Lourdes
Number of Pages: 104 pages
Published Date: 07 May 2014
Publisher: Publicia
Publication Country: United States
Language: Spanish
Format: Pdf
ISBN: 9783639551952
File Name: Muerte.Neuronal.En.La.Enfermedad.de.Huntington.pdf
Download Link: Muerte Neuronal En La Enfermedad de Huntington
---------------------------------------------------------------
La enfermedad de Huntington (EH) es un padecimiento hereditario, neurodegenerativo que se caracteriza por la presencia de movimientos involuntarios, demencia y alteraciones psiquiatricas. La mutacion de la proteina conocida como "huntingtina" lleva al desarrollo de la EH, afectando principalmente la funcion de las neuronas espinosas medianas (NEM) en el caudado-putamen (estriado). Desafortunadamente, las NEM no pueden compensar los cambios originados por la huntingtina y eventualmente mueren. Se ha sugerido que a traves de un mecanismo excitotoxico (toxicidad mediada por el glutamato), ya que alteraciones en los componentes de la transmision glutamatergica ocurren tempranamente en pacientes y modelos transgenicos de la EH. En este trabajo evaluamos la toxicidad del glutamato en el estriado de un modelo transgenico de la EH. Tambien estudiamos la relacion entre la excitotoxicidad y los niveles de los transportadores de glutamato en la EH. Nuestros resultados indican que las NEM son mas vulnerables a la toxicidad mediada por glutamato; el desarrollo de un evento excitotoxico en la EH esta estrechamente relacionado con los cambios funcionales de los transportadores glutamato."
Read online Muerte Neuronal En La Enfermedad de Huntington Buy and read online Muerte Neuronal En La Enfermedad de Huntington Download and read Muerte Neuronal En La Enfermedad de Huntington ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent Download to iPad/iPhone/iOS, B&N nook Muerte Neuronal En La Enfermedad de Huntington